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Charlotta Schärfe

Since 2011: PhD student at Applied Bioinformatics Group
09/2013 - 09/2014: Research visit at Debora Marks lab, Harvard Medical School, Boston, MA 


Theses

C. Schärfe. Humane Papillomviren und Krebs. Bachelor Thesis. Universität Tübingen. 2010
 

C. Schärfe. A Critical Assessment of the Impact of Computational Methods on the Productivity in Pharmaceutical Research and Development. Master Thesis. University of Warwick. 2011 

Publications

J.M. Nicoludis, S. Lau · C.P.I. Schärfe, D.S. Marks, W.A. Weihofen, R. Gaudet Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity. StructureOct 10. pii: S0969-2126(15)00375-5 (available online DOI: 10.1016/j.str.2015.09.005), 2015
 
M. Avbelj, O. Wolz, O. Fekonja, M. Benčina, M. Repič, J. Mavri, J. Krüger, C.Schärfe, M.D. Garcia, G. Panter, O. Kohlbacher, A.N.R. Weber, R. Jerala
Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization, Blood, 124 (26) 3896-3904 (available online: DOI: 10.1182/blood-2014-05-573188), 2014
 
Y. Gofman, C. Schärfe, D.S. Marks, T. Haliloglu, N. Ben-Tal Structure, Dynamics and Implied Gating Mechanism of a Human Cyclic Nucleotide-Gated Channel, PLoS Comput Biol 10(12): e1003976 (available online: DOI:10.1371/journal.pcbi.1003976), 2014
 
T.A. Hopf*, C.P.I. Schärfe*,  J.P.G.L.M. Rodrigues*, A.G. Green, O. Kohlbacher, C. Sander, A.M.J.J. Bonvin, D.S. Marks Sequence co-evolution gives 3D contacts and structures of protein complexes. eLife Sep 25;3. (available online DOI: 10.7554/eLife.03430), 2014
 
R. Grunzke, S. Breuers, S. Gesing, S. Herres-Pawlis, M. Kruse, D. Blunk , L. de la Garza, L. Packschies , P. Schäfer, C. Schärfe, T. Schlemmer , T. Steinke, B. Schuller , R. Müller-Pfefferkorn, R. Jäkel , W. Nagel , M. Atkinson and J. Krüger: Standards-based metadata management for molecular simulations, Concurrency and Computation: Practice and Experience, (available online DOI: 10.1002/cpe.3116), 2013.
 
L. de la Garza, J. Krüger, C. Schärfe, M. Röttig, S. Aiche, K. Reinert and O. Kohlbacher  From the desktop to the grid: conversion of KNIME Workflows to gUSE, Proc. of 5th Workshop IWSG 2013, June 3-5 2013, Zurich, Switzerland, CEUR Workshop Proceedings, ISSN 1613-0073, 2013. 
 
L. Packschies,G.  Birkenheuer, D. Blunk, S.  Breuers, A.  Brinkmann, L. de la Garza, I. dos Santos Vieira, G. Fels, S. Gesing, R. Grunzke, S. Herres-Pawlis, O. Kohlbacher, J. Krüger, M. Kruse, U. Lang, R. Müller-Pfefferkorn, P. Schäfer, T. Schlemmer, C. Schärfe, T. Steinke, K.-D. Warzecha, A. Zink. The MoSGrid – E-Science Gateway: Molecular Simulations in a Distributed Computing Environment. 8th German Conference on Chemoinformatics. Goslar. Nov. 2012
 

Talks

C. Schärfe, J. Taeger, P. Reuter, N. Fischer, J. Krüger, B. Wissinger, O. Kohlbacher. Development of a Pharmacophore Model for Pharmacological Chaperones Targeting Mutant Trafficking-Deficient CNG Channels. 8th German Conference on Chemoinformatics. Goslar. Nov. 2012
 
T.A. Hopf*, C.P.I. Schärfe*,  J.P.G.L.M. Rodrigues*, A.G. Green, O. Kohlbacher, C. Sander, A.M.J.J. Bonvin, D.S. Marks Sequence co-evolution gives 3D contacts and structures of protein complexes, Highlights ISMB 2015

Latest content created by this user

Article Reference
Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4 Oct 02, 2016
Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity Oct 02, 2016
Bibliography Folder
Publications Nov 15, 2012
Page
Moab FAQ Dec 17, 2014
Practical course - Applied Structure-Based Drug Design Aug 17, 2010
KNIME Sep 12, 2013
Tutorials Apr 08, 2013
Lecture Drug Design 2 Sep 08, 2009
File
Syllabus DD2 SS2016 Mar 17, 2016
Syllabus DD2 Sep 02, 2015
DD2_SS13_11_QSAR_IV_3up.pdf Jul 18, 2013
DD2_SS13_11_QSAR_IV.pdf Jul 18, 2013
DD2_SS13_10_QSAR_III_3up.pdf Jul 18, 2013
Folder
WS 2013/14 Sep 12, 2013
Projects Jun 06, 2013
Assignment Sheet 4 May 16, 2013
Assignment Sheet 3 May 02, 2013
Assignment Sheet 2 Apr 25, 2013
Mastersthesis Reference
A Critical Assessment of the Impact of Computational Methods on the Productivity in Pharmaceutical Research and Development Nov 15, 2012
News Item
Philipp Thiel received his PhD Feb 06, 2015
Nina Fischer received her PhD Sep 02, 2013
PDF File
A Critical Assessment of the Impact of Computational Methods on the Productivity in Pharmaceutical Research and Development Nov 15, 2012
PDF Folder
PDFs Nov 15, 2012
All content created by Charlotta Schärfe…