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Daniel J Kowalewski, Heiko Schuster, Linus Backert, Claudia Berlin, Stefan Kahn, Lothar Kanz, Helmut R Salih, Hans-Georg Rammensee, Stefan Stevanovic, and Juliane S Stickel (2015)

HLA ligandome analysis identifies the underlying specificities of spontaneous antileukemia immune responses in chronic lymphocytic leukemia (CLL)

Proceedings of the National Academy of Sciences of the United States of America, 112(2):E166–E175.

Effective cancer immunotherapy relies on specific immune recognition of tumor-associated and tumor-specific antigens. In chronic lymphocytic leukemia (CLL), the highly variable course of disease implicates an underlying mechanism of tumor control by the immune system. In this study, we directly analyzed the landscape of naturally presented CLL antigens and identified targets conveying immune protection. These novel antigens might be valuable both for patient stratification and for inducing therapeutic antitumor immunity. Taken together, we demonstrate that CLL is subject to spontaneous T-cell responses targeting nonmutated antigens, which are associated with improved patient survival and provide novel options for the immunotherapy of CLL.

10.1073/pnas.1416389112